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Valproic acid, which has been used as an antiepileptic drug for many years and still is used in this indication, has been shown to inhibit preferably class I HDACs in the high micromolar to millimolar range

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Patients with diabetes already face a higher risk of atrial fibrillation, so understanding how these GLP-1 receptor agonists affect cardiac electrophysiology is essential

However, it never made it as a stand-alone agent for obesity as it caused some issues with mood and memory