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Dipeptidyl peptidase-4 (DPP-4) is the main enzyme responsible for GLP-1 breakdown, and cleaves GLP-1 to produce inactive forms, including GLP-1(9-36) amide or GLP-1(9-37), reducing its biological activity (22,32,33)
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This widespread receptor distribution causes effects in multiple organ systems
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Retatrutide Phase 2 trials used doses ranging from 1 mg to 12 mg weekly, with the 12 mg cohort showing the most significant weight loss
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