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Voltage-gated sodium channels were blocked by 0.5 M tetrodotoxin (TTX) (Tocris)

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For example, if the desired dose is 250 mcg: Required volume = Desired dose Concentration 250 mcg 500 mcg/mL = 0.5 mL In this example, 0.5 mL of solution contains 250 mcg of peptide

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