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Indeed, superoxide can undergo dismutation to H 2 O 2 , a mild oxidant that can be converted to the highly reactive hydroxyl radical in the presence of transition metals (Fe 2 + , Cu + ) by means of the Fenton reaction
Funding Funding by the Danish Research Foundation (Den Danske Forskningsfond) was granted to ATL and SGY (Grant numbers N/A)
These conditions result in the overproduction of AGEs, accumulation of pro-inflammatory and pro-fibrotic factors, and free fatty acid oxidation
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