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"And so there are going to be people who have major depressive disorder, who may be getting treatment, but may have an enhanced susceptibility to having worsening anxiety or depression on these drugs that we just did not account for." After, reviewing the FAERS reports NPR found, Rothberg said almost every patient listed had an underlying major health condition that, based on the database alone, would make it hard to determine whether the drug caused the suicidal thoughts

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Tirzepatide is administered as a subcutaneous injection once weekly , on the same day each week, at any time of day, with or without food

Managing vomiting requires dose reduction, slower titration, dietary modifications, and occasionally antiemetic medications

GLP-1 therapy can compound this risk