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Potent GLP-1 agonists exert effects by multiple mechanisms including delayed gastric emptying, increased glucose-dependent insulin secretion, reduced glucagon levels, and reduced food intake by CNS effects to cause appetite suppression
Y2R receptor is present in the brain and its agonism results in a reduction in food intake and increased satiety [91]
Carnitine metabolism in chronic liver disease
- May help the body to detoxify
In neuronal systems, Akt phosphorylation downstream of GLP-1R contributes to neuronal resilience in models of Alzheimers and PD [38]
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