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However, dedicated studies investigating currently recommended GLP-1Ra (semaglutide, dulaglutide, and liraglutide) in ACS patients are still lacking, and the only trial exclusively enrolling patients with recent ACS - the ELIXA trial - failed to demonstrate the superiority of lixisenatide over placebo [42]

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Contraindications Noted in Published Research Because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, the literature consistently identifies active or prior malignancy, and precancerous conditions, as contraindications for IGF-1 LR3 research use

K., Rastogi, A., Bansal, A., Donnelly, J