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GERD can sometimes cause weight loss due to difficulty swallowing or loss of appetite

doi: 10.3389/fnut.2025.1615671 Received 21 April 2025 Accepted 29 July 2025 Published 13 August 2025 Volume 12 - 2025 Edited by Ismael San Mauro Martn, CINUSA Group, Spain Reviewed by Simone Birgit Bayer, University of Otago, Christchurch, New Zealand Emanuela Ribichini, Sapienza University of Rome, Italy Aleksandar Sic, Advocate Illinois Masonic Medical Center, United States Updates Copyright 2025 Khan, Brnstad, Hillestad, Steinsvik, Hausken, Berentsen and Lied

Moreover, the addition of -ketoglutarate (-KG), a metabolite derived from glutamate, effectively restored the viability of cancer cells with elevated levels of SLC7A11 during glucose deprivation, indicating a potential role for exported glutamate in promoting cancer cell death (59)

Tirzepatide ( Mounjaro ), on the other hand, is a dual-action medication, acting both as a GLP-1 agonist and a GIP (glucose-dependent insulinotropic polypeptide) receptor agonist

In db/db mice, exendin-4 (EX-4) significantly suppressed the overexpression of pyroptosis-related proteinsincluding ASC, caspase-1, IL-1, and GSDMD