DOI: 10.2337/db08-1193 [Google Scholar] Guan G, Zhang J, Liu S, Huang W, Gong Y, Gu X
doi: 10.3390/jcm12020672 74 AnsariZMalekiMHRoohyFEbrahimiZShamsMMokaramPet al
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C9SN modifies the immunosuppressive tumor microenvironment (ITM) by impeding glutamine metabolism on one hand, polarizing M2-TAMs to M1-TAMs, which in turn recruits and activates CTLs, while on the other hand, C968 in the nanoaugmentation amplifies the intracellular oxidative stress by inhibiting glutamine metabolism-mediated GSH deprivation, which results in severe cell death, and also enhances the immunogenic cell death (ICD) effect [122]