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& Simon, M
Consider the evidence quality
In REDEFINE 2, which included participants with type 2 diabetes (a population that typically shows lower weight loss with any intervention), CagriSema achieved 13.7% weight loss compared to 3.4% with placebo
The majority of participants (65.6%) reported current use of GLP-1, while the remaining 34.4% had used them previously
The nausea, vomiting, and diarrhea commonly associated with semaglutide therapy can lead to reduced fluid intake or increased fluid loss, potentially resulting in dry mouth (xerostomia)
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