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DEA's own review notes that many users report self-treating chronic pain and anxiety, and that users describe moving from traditional kratom leaf to concentrated 7-OH tablets

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In haemorrhagic shock models (superior mesenteric artery occlusion), BPC-157 reduces mortality and improves organ perfusion scores an effect abolished by L-NAME, confirming NO pathway dependence

They are, at best, an adjunct one that might offer significant benefit for carefully selected patients under qualified medical supervision