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doi: 10.1016/S0197-4580(97)00037-7 90 FrakesA
A Sharp Rise in Calls and a Changing Patient Profile Researchers analyzed 10,033 reported drug exposure cases drawn from the National Poison Data System, a database maintained by Americas Poison Centers that compiles records from poison control centers across all U.S
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Phase 2 clinical trials published in 2023 reported mean resting heart rate increases of approximately 5 to 7 beats per minute at higher doses (8 mg and 12 mg weekly)
Patients with certain genetic profiles may require slower titration, lower maintenance doses, or closer monitoringpersonalization that reduces overdose risk and side effect severity
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