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Half-Life of Retatrutide: What the Clinical Data Shows The half-life of retatrutide is approximately 6 days, achieved through albumin-binding via a C20 fatty diacid moiety, meaning steady-state concentrations are reached after around four to five weeks of once-weekly dosing
J Neurosci 27 : 54745483
10.1093/humupd/dmac035 93 LiL.ChenJ.ChenJ.WangY.PeiY.WangM.et al (2024)
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The head-to-head trial results in December 2026 will clarify the picture
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