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Metabolites such as HMGB1 and glutamate released by dead cells can reshape the immune microenvironment through a dual mechanism (153): HMGB1 binds to TLR4 on the surface of DCs, activates the NF-B pathway to promote DC maturation and MHC molecule expression, and then activates tumor antigen-specific CD8+ T cells
iScience 24 , 101902 (2021)
10.1089/ars.2016.6866 82 YuF.YuC.LiF.ZuoY.WangY.YaoL.et al (2021)
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