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VD is particularly vulnerable: enzyme-inducing ASMs (e.g., phenytoin and carbamazepine) activate PXR pathways, which up-regulate CYP24A1 and CYP3A4
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These are studies that show correlation, in populations where many factors simultaneously influence both the decision to take pain medication and the development of a child's neurology
The perspective outlined here emphasizes regenerative capacity relative to metabolic flux rather than absolute accumulation of reactive oxygen species
doi: 10.1073/pnas.97.22.11869 63 ZuccaFAVannaRCupaioliFABelleiCDe PalmaADi SilvestreDet al
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