GHK-CU tends to be gentlest
44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops
The compound did not appear to affect food intake, behavior, or general health status in treated animals
The most honest assessment: AOD-9604 before-and-after results at 12 weeks look like a slightly accelerated version of what a clean diet and exercise program would produce alone
Targeted inhibition of NNMT improves insulin responsiveness and may protect against diet-induced obesity. Hong et al., Nature Medicine Longevity and Anti-Aging Potential Because NAD is vital for DNA repair, circadian rhythm regulation, and mitochondrial health, 5-Amino-1MQ is being explored as a geroprotective agent especially when stacked with NAD boosters or sirtuin activators