Mechanistic follow-up tied the raised SAM levels to elevated H3K4 histone methylation at promoters of favorable metabolic genes including PGC-1alpha (PPARGC1A), a master regulator of mitochondrial biogenesis and thermogenic programs, providing a plausible NNMT to SAM to histone-methylation to gene-expression chain
IM therapies include nutrients that are fat soluble and thus stay in the body for a duration of time, while IV therapies include nutrients that are all water soluble which means that your body will use what it needs and then eliminate what it doesnt need avoiding toxic levels
Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N
How might that matter for ulcerative colitis or other colitis states
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