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In clinical studies the numbers are unusual for a sleep aid: DSIP increased total sleep time by about 59% in one trial, normalized sleep in people with chronic insomnia in another, and, most strikingly, several of those patients kept normal sleep for 3 to 7 months after their last injection
Although most studies suggest that GLP-1RAs promote weight loss mainly due to their inhibitory effect on food intake, other central effects that have been described for native GLP-1 and some GLP-1RAs in rodents and humans encourage future clinical trials to explore additional mechanisms that potentially underlie the beneficial effects observed with this drug class
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Retatrutide is a triple agonist that activates three receptors: GLP-1, GIP, and Glucagon
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