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Konig SA, Siemes H, Blaker F, Boenigk E, Gross-Selbeck G, Hanefeld F, Haas N, Kohler B, Koelfen W, Korinthenberg R: Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities

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Because the liver is one of the main sites for carnitine synthesis, liver disease can impair carnitine synthesis, which further aggravates the above-mentioned pathological processes and promotes disease progression