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Under low testosterone levels, the expression of genes related to glucose transport is downregulated, including insulin receptor substrate 1 (IRS-1), insulin receptor subunit (IR-), glucose transporter 4 (GLUT4), AKT serine/threonine kinase-2 (AKT2), and solute carrier family 2 member 4 (SLC2A4) [150, 151]
The compound is not listed on any controlled substance schedule in the US, meaning possession without intent to distribute exists in a legal gray area rather than being explicitly prohibited
& Brinker, A
Zepbound activates GLP-1 and GIP receptors simultaneously-reducing appetite significantly within days, slowing gastric emptying by approximately 40%, and producing average weight loss of up to 21% by week 72
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