5-Amino-1MQ inhibits an enzyme involved in fat metabolism
Inhibition of NNMT rebalances cellular methyl economy and NAD salvage flux, with downstream effects on adipocyte energetics, lipid handling, and insulin action observed in preclinical systems [13]
Mountjoy, M., Sundgot-Borgen, J., Burke, L., et al
The ability to shuttle between the +1, +2, and +3 oxidation states is responsible for the versatile chemistry of vitamin B 12 , allowing it to serve as a donor of deoxyadenosyl radical (radical alkyl source) and as a methyl cation equivalent (electrophilic alkyl source)
As many as 40-50% of Hypothyroid patients have a B12 deficiency (2)