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Investigators found that in many cases, high-potency, non-FDA-approved botulinum toxin products intended for research or veterinary use had been injected by unlicensed or minimally licensed providers, often in non-clinical settings
They enrolled 130 patients with ALS, dividing the patients equally into the treatment group receiving an ultrahigh dose (50 mg) of methylcobalamin and the placebo group
When adverse effects do occur following high-dose B12 administration, they are typically mild, transient, and often related to the route of administration rather than the vitamin itself
NG239 Vitamin B12 deficiency in over 16s: diagnosis and management risk factors and symptoms
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