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Curr Genomics
387 :e12 171
Several sub-cellular compartments generating ROS have been identified, including cytosol, peroxisomes, plasma, and endoplasmic reticulum (ER) membranes [26, 27]
In order to study how the metabolism of APAP affects GSH concentration and resynthesis, we have connected the model depicted in Figure1 to our extant model of glutathione metabolism[9]
Once released, the GR amino acids that interact with the drug are Phe209, Ala319, Ile350 and Val354 at a distance of 2 to 4 and also with residues Tyr180, Leu321, Lys318, Leu320, and Thr352 (Thr352 forms several polar and hydrogen bonding interaction at 2.2 to 3.2 ) that stabilizes the carmustine in the binding pocket (Fig
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