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They identified gastrointestinal (GI) issues, particularly vomiting and nausea, as the most common side effects for most GLP-1 RAs, while headache and joint pain were most frequently discussed in posts about tirzepatide

Alyssa Dominguez, an endocrinologist at Keck Medicine of USC

One prevailing theory is that tirzepatide is an imbalanced and biased GLP-1 RA with very low efficacy for recruitment of -arrestin, whilst is acting as an unbiased GIP agonist with full efficacy for -arrestin recruitment [51, 52]

Your dermatologist will decide how often to provide the injections

Because this is still an investigational compound, we frame the science honestly: what is genuinely studied, and what remains unknown