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Patients should always consult qualified healthcare professionals regarding peptide therapy options, treatment plans, and safety considerations

Yki-Jarvinen H (2007) ADOPT: lessons from comparison of glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

Retatrutide has drawn attention because it isn't being framed as just another step in the same direction

The bottom line: Our findings suggest that GLP-1RA and SGLT2i (and especially SGLT2i with the lowest number needed to treat (NNT) for nearly all study outcomes) may be the preferred glucose-lowering agents for cardiovascular risk reduction in patients at moderate risk for CVD, building on and consistent with existing RCT evidence in the high-risk population. This report highlights potential preference for GLP-1 drugs as a first-line treatment for Type 2 diabetes related to its cardioprotective effect

doi:10.1523/JNEUROSCI.3262-11.2011 Volkow ND & Xu R (2025)