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However, because B12 is stored in our livers, it might take a while for these deficiencies to show (Glass, 1959)
280 The accumulation of unfolded or misfolded proteins triggers the unfolded protein response (UPR), an adaptive signaling network coordinated by the endoplasmic reticulum sensors IRE1, PERK, and ATF6, which functions to restore proteostasis and maintain cellular homeostasis
Conversely, some patients report temporary digestive changes as their system readjusts to the absence of the medication
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