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A 2026 network meta-analysis including over 13,000 participants found that tirzepatide intervention produced significantly better results than semaglutide across multiple measures, not just weight loss, but also improvements in blood sugar control and metabolic health markers

What did the FDA committee members decide

Losing muscle can reduce metabolic rate, making it harder to sustain weight loss and leading to a host of other health issues, such as decreased strength and mobility

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