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lesion area covering 1030% of BSA is defined as SJS/TEN

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In a staphylococcal infection setting, riboflavin has demonstrated its anti-inflammatory property through reductions in NF-B, COX2 (cyclooxygenase 2), TNF-, NO, IL-1 (interleukin 1 beta) reducing iNOS (inducible NO synthase) synthesis, as well as an elevation in anti-inflammatory cytokine IL-10 (interleukin 10), and modulation of MCP-1 (monocyte chemoattractant protein 1) function, a potent chemoattractant (34)