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Clinically, this means: if you have manageable constipation at 0.5 mg and your provider wants to escalate to 1.0 mg, expect symptoms to worsen during the transition

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Studies that reported only vascular disorders or vascular adverse events as combined adverse effects without distinction were not analyzed.1924 These events included hypo- and hypertension, and thrombotic, ischemic or hemorrhagic vascular episodes in any territory