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The RENAAL trial (N=1,513), which established losartan's renal protective benefit in type 2 diabetic nephropathy, excluded patients on chronic systemic corticosteroids precisely because of confounding renal and metabolic effects [9]

And as you can see on this graphic in this study of patients for whom multiple other antimanic drugs didnt work, we see significant reductions down the line in mania symptoms, depression symptoms, global improvement, positive symptoms, negative symptoms

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