Earlier Predictive Value: During early acute liver injury, GR activity rises significantly, with its peak appearing earlier than that of transaminases (ALT, AST), providing a more timely window for clinical intervention [4] Major liver disease guidelines from the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) emphasize the need to detect early hepatocyte stress and dysfunction, particularly in conditions like drug-induced liver injury [5,6]
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Despite all the progress made in MS approaches, such as improving the detection limit to the sub-attomole to zeptomole range, there are still some limitations in using it at the single cell level (Liu et al., 2019)
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