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Hopkins ND, Cuthbertson DJ, Kemp GJ, Pugh C, Green DJ, Cable NT, et al
More serious but rare side effects include gallbladder problems and pancreatitis (inflammation of the pancreas)
M.LebherzC.et al (2014)
10.1016/j.neuron.2016.12.017 6 BendavitG.AboulkassimT.HilmiK.ShahS.BatistG
Future directions include structural modifications to enhance brain targeting (e.g., curcumin nanocrystals, resveratrol phosphate prodrugs), identification of core pharmacophores and direct targets using chemical biology techniques (such as ABPP and CETSA), establishment of standardized evaluation systems for ferroptosis-inhibition potency to enable cross-comparison of EC 50 and therapeutic indices across consistent cell and animal models, and the development of combination strategies integrating natural compounds with synthetic inhibitors (e.g., low-dose Lip-1 with curcumin) to reduce dosage, minimize side effects, and enhance therapeutic efficacy
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