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Treg highly express GPX4 to maintain their own antioxidant capacity: GPX4 deficiency leads to increased accumulation of intracellular lipid peroxides and ferroptosis, thereby relieving immunosuppression of effector T cells (219)
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The review provides an introduction to the reproductive toxicity of SSRIs from the aspects of male and female germ cell genesis, embryonic development, reproductive system maturation, and environmental contamination, and it briefly describes the potential mechanisms underlying SSRI-induced reproductive toxicity
El-Shorbagy HM
These metabolites bind to Takeda G protein coupled receptor-5 TGR5 receptor (G-protein-coupled bile receptor) present in the endocrine glands, adipocytes, muscles, immune organs, spinal cord and enteric nervous system, and stimulates the secretion of incretin hormone GLP-1 and insulin
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