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In the Wegovy clinical program, gastroesophageal reflux disease was reported in 5% of participants, dyspepsia in 9%, and eructation in 7%, alongside nausea at 44%, diarrhea at 30%, vomiting at 24%, and constipation at 24%

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However, sensitivity analyses indicated that the overall effect was robust, suggesting that this risk signal was not driven by any single study but might reflect the true variable effects of GLP 1RA on mental health across different populations and study designs

In patients with type 2 diabetes (T2DM), an impaired insulin response to GLP-1 and GIP contributes to hyperglycemia