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When looking at the public overall, 12% of all adults report ever taking these drugs at least in part to treat a chronic condition, including 7% of the public who say they took them primarily to treat a chronic condition and 6% who say they took these drugs to both treat a chronic condition and to lose weight
In: New Aspects in Analyzing the Synaptic Organization of the Brain
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This has been experimentally demonstrated by silencing the estrogen receptor in breast cancer (ER+) with consequent decrease of OCTN2 expression (Wang et al., 2012)
Their mechanism creating a transient ternary complex with POIs, E3 ligases, and PROTACs minimizes susceptibility to protein mutations and enhances their potential to overcome drug resistance 39
