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(Weinh.) 11 , e2406184 (2024)
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Melanotan-1 Research Overview Melanotan-1 is a synthetic analog of alpha-melanocyte stimulating hormone (-MSH)
PMID: 18635433 | DOI: 10.1056/NEJMct0708278 [7] Rushworth GF, Megson IL
Studies were not excluded based on their risk of bias rating, but results from those with higher risk should be interpreted with caution
Key quantitative findings included dose-dependent increases in CXXC5 expression following PGD2 treatment, corresponding decreases in beta-catenin and PCNA (a proliferation marker), restoration of Wnt signaling and cellular proliferation with PTD-DBM treatment, and complete resistance to PGD2-induced hair loss in CXXC5 knockout mice
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