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While free NAPQI is the direct cause of toxicity, it cannot be detected or quantified in its free form in plasma or assay buffers due to its immediate reactivity with thiols and proteins
Awareness of both common and serious side effects helps patients use the drug safely
1 Introduction Osteoarthritis (OA) is among the most prevalent degenerative joint diseases globally, affecting more than 500 million people worldwide and ranking as the leading cause of disability among adults aged 50 years and older (1, 2)
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