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As shown on the right panel, aspirin irreversibly inhibits COX activity by acetylation of a serine residue in the active site for COX (SER 529 in COX-1 & SER 516 in COX-2)
These include GLP1/glucagon dual agonists (AstraZeneca, Boehringer Ingelheim, Hanmi Pharma, Eli Lilly) , GIP/GLP1/glucagon tri-agonists (Hanmi Pharmaceuticals, Eli Lilly), or solo GIPR agonists (Eli Lilly, Zealand Pharma)
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