Here are signs that your dose may need adjustment: Signs the dose is too high: Persistent nausea beyond 3 weeks at current dose level Regular vomiting (more than once per week) Severe constipation not responding to hydration and fiber Food aversion (inability to eat adequate nutrition) Rapid weight loss exceeding 1.5% of body weight per week Signs the dose is too low: No noticeable change in appetite or satiety Minimal or no reduction in food intake Weight has plateaued for 4 or more weeks No gastrointestinal effects whatsoever (some mild effects indicate the drug is working) Signs you are at the right dose: Moderate appetite suppression (eating less without feeling starved) Steady, sustainable weight changes Mild or no side effects Improved satiety (feeling satisfied with smaller portions) Stable energy levels throughout the day Finding the right dose is a process

Because it targets two hormones, endocrinologists sometimes see greater results in people struggling to lose weight despite lifestyle measures
Magnesium can also interact with certain blood pressure medications and diuretics by amplifying their effects or depleting electrolyte balance
Aroda VR, Rosenstock J, Wysham C et al (2016) Efficacy and safety of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide in type 2 diabetes inadequately controlled on basal insulin and metformin: the LixiLan-L randomized trial
Vigilant Monitoring: Distinguishing Normal Reactions from Infection After injection, monitor for signs of possible contamination, including: Fever Increasing redness or warmth at the injection site Swelling Unusual pain These symptoms could indicate infection and require immediate medical attention