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In exploring the treatment of obesity and its associated complications, such as Type 2 diabetes and cardiovascular disease, a prominent and popular target is the Glucagon-Like Peptide-1 Receptor (GLP-1R)
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Virmani MA, Krsmanovic LZ, Stojilkovic SS, Catt KJ
Both male and female mice were housed under controlled conditions of 12 h:12 h light-dark cycles and at 22 C temperature and 4555% humidity and fed ad libitum a standard rodent chow diet (CHD) or high fat diet (HFD) (60% of calories from fat) for 12 (males) or 24 (females) weeks starting at week 8 of age
They point out that there is not enough scientific evidence to support any of these uses
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