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Topical application is the preferred route for cosmetic-adjacent skin research because it delivers the peptide directly to the target tissue while avoiding systemic exposure

But, because the MenB strains that cause invasive meningococcal diseases are highly diverse with respect to the quantity and immunological cross-reactivity of the vaccine antigens expressed, estimating the effectiveness of the vaccine required performing SBA against large numbers of isolates, an undertaking that was judged to be impractical