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Most patients who combine both report improved metabolic outcomes

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The recent meta-analyses indicated that in patients with high TMAO plasma level, the incidence of major adverse cardiovascular events was significantly higher compared with patients with low TMAO levels [67], and that all-cause mortality increased by 7.6% per each 10 mol/L increment of TMAO [68]

This latter benefit may make it possible to more adequately treat psychiatric conditions, which are notoriously difficult to treat, in part because patients often discontinue their medications secondary to severe side effects

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