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In the DURATION program for type 2 diabetes: DURATION-1 : Exenatide ER (Bydureon) 2 mg weekly produced 3.7 kg weight loss over 30 weeks DURATION-5 : Bydureon produced 2.3 kg weight loss over 24 weeks Three-year data : Sustained weight reduction of approximately 2.3 kg (5.1 lbs) from baseline Exenatide is not FDA-approved for chronic weight management