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Insulin gene transcription and translation, as well as the enhancement of glucose-stimulated insulin secretion (insulinotropic effects), are caused by GLP- 1 receptor activation in the beta cell
Wider provision of the drugs through government-sponsored healthcare services, such as Medicare and Medicaid in the US, would be expected to further increase uptake and persistency, especially if prices are materially reduced through negotiated discounts with the pharmaceutical industry
Beyond the legal risk, unregulated versions of peptide drugs carry serious contamination and dosing risks
GLP-1 also slows gastric emptying, reduces appetite, and decreases glucagon secretion, helping prevent excessive rises in blood sugar after meals
That matters because GLP-1 treatment is not one-size-fits-all
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