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Surgery may be necessary in extreme cases if the anal fissure occurs with symptoms of black tarry stool in adults
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Whatever the reason, the clinical development program ended
The mechanisms are not fully understood but may involve GLP-1 receptor distribution in the central nervous system, gastrointestinal effects, dehydration, or vascular changes
Emulsify with a small amount of water and rinse off thoroughly
Some lose more (5 to 7 lb) if they had been eating substantially over their maintenance calories before starting
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