Beyond glycaemic control, Ozempic has been shown in clinical trials (SUSTAIN-6) to reduce cardiovascular events in people with type 2 diabetes and established cardiovascular disease, although this is not a separate licensed indication in the UK
The FDA has approved its use for chronic weight management in adults with a body mass index (BMI) of 30 or more, or a BMI of 27 or more when accompanied by at least one weight-related condition such as high blood pressure, high cholesterol, or type 2 diabetes
20 Thus, drugs utilising GIP, GLP-1, or GLP-2 receptor signalling pathways are already in clinical use, which should make potential application within the bone disease arena less complicated ( Figure 3 )
Using plain sterile water requires single-use handling and significantly shortens stability
Furthermore, clinical trials evaluating oral glutathione have shown that consistent supplementation can significantly enhance immune function markers