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Since we did not detect a decrease in pyruvate in the cortex (Supplementary Table 7), these results could suggest there may be reduced lactate dehydrogenase activity in astrocytes, as lactate can be produced downstream from glucose to support energy needs in neurons

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Supplementation with sialic acid showed restoration of IGF-1R distribution in GNE deficient cell lines similar to vector control

To view a copy of this licence, visit About this article Cite this article Zhang, Q., Chen, D., Ding, H

Van Biesen, W., Lameire, N., Vanholder, R