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Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), constitute an escalating worldwide health challenge, with prevalence estimates reaching one-quarter of adults globally

Stress resistance in long-lived mouse models

Neurons, astrocytes, and oligodendrocytes all express it, and IGF-1 signaling has documented roles in neurogenesis, synaptogenesis, myelination, and neuronal survival

It decreased glycated hemoglobin (HbA1c) by 0.78% at maximum dosages [88]

Lee DH, Jacobs DR Jr, Gross M, Kiefe CI, Roseman J, Lewis CE, Steffes M