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In macrophages, the upregulation of 15-LOX expression catalyzes AA dioxide, leading to lipid peroxidation, which triggers ferroptosis in macrophages (51)

doi: 10.1002/glia.22647 242 NordenD

pylori -colonized host gastric epithelial cells with defects of DNA repair are more inclined to oxidative stress and DNA damage, which significantly intensify the risk of gastric cancer [143, 144]

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