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A summary of their status, interventions, follow-up durations, and main outcomes is shown in Table 4

In this context, therapies such as GLP-1RAs may represent a complementary strategy aimed at modulating both metabolic dysfunction and inflammation, thereby optimizing disease control and improving long-term outcomes in PsA

PLoS Biol (2006) 4(11):e374.10.1371/journal.pbio.0040374 116 SzegezdiELogueSEGormanAMSamaliA

The three recommended sites are the abdomen, thigh, and upper arm, each with its own benefits

However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease